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Neonatal thrombosis and its treatment
A Greenway1, M P Massicotte, P Monagle
1Division of Laboratory Services, Royal Children's Hospital, Department of Paediatrics, University of Melbourne, Melbourne, Vic., Australia.
Blood Reviews
|March 11, 2004
Summary
Neonatal thromboembolic disease (TE) is a growing concern in intensive care. This review examines the epidemiology, diagnosis, and treatment of TE in newborns, highlighting the need for more research.
Area of Science:
- Neonatal Medicine
- Pediatric Thrombosis
- Vascular Health
Background:
- Thromboembolic disease (TE) is increasingly recognized as a significant complication in neonatal intensive care units.
- Improved survival rates for premature and critically ill newborns have coincided with a rise in associated complications, including thrombosis.
- The long-term consequences of thrombosis in neonates are an emerging area of concern.
Purpose of the Study:
- To systematically review the epidemiology of arterial and venous TE in neonates.
- To evaluate diagnostic strategies and outcomes for neonatal TE.
- To assess the role of inherited thrombophilic abnormalities and anticoagulation therapy in neonatal TE.
Main Methods:
- Systematic literature review.
- Analysis of epidemiological data on neonatal thromboembolism.
- Evaluation of diagnostic methods and treatment outcomes.
Main Results:
- Neonatal TE is a significant and increasing problem, particularly in premature infants.
- Current evidence on optimal diagnostic strategies and treatments is limited.
- Inherited thrombophilic factors may play a role, but their impact requires further investigation.
Conclusions:
- Neonatal thromboembolic disease represents a critical challenge in pediatric care.
- There is a substantial lack of high-level evidence to guide optimal diagnostic and therapeutic approaches.
- Urgent research is needed to improve the management and outcomes of neonatal TE.