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Related Experiment Videos

Controlled-release codeine is equivalent to acetaminophen plus codeine for post-cholecystectomy analgesia.

Frances Chung1, Doris Tong, Paula C Miceli

  • 1Department of Anesthesia, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada. frances.chung@uhn.on.ca

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|March 11, 2004
PubMed
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Controlled-release codeine (CC) offers comparable pain relief and patient satisfaction to acetaminophen plus codeine (A/C) after surgery. CC provides this benefit with less frequent dosing, enhancing postoperative pain management.

Area of Science:

  • Anesthesiology and Pain Management
  • Surgical Recovery
  • Pharmacology

Background:

  • Post-ambulatory surgery pain management often utilizes analgesics.
  • Long-acting analgesics may offer benefits over short-acting formulations.
  • Optimizing pain control and patient satisfaction is crucial for surgical recovery.

Purpose of the Study:

  • To compare the efficacy of controlled-release codeine (CC) versus acetaminophen plus codeine (A/C) for postoperative pain control.
  • To evaluate pain reduction, onset of analgesia, and patient satisfaction following laparoscopic cholecystectomy.
  • To assess the safety and tolerability of CC and A/C in the 48-hour postoperative period.

Main Methods:

  • A double-blind, double-dummy, parallel group study randomized 84 patients into CC or A/C groups.

Related Experiment Videos

  • Pain was assessed using a 100 mm visual analogue scale (VAS) at multiple time points up to 48 hours post-surgery.
  • Adverse events and patient satisfaction were systematically recorded.

    • Main Results:

    • No statistically significant differences were observed between CC and A/C in mean VAS baseline pain or time to onset of analgesia.
    • Both treatment groups showed significant VAS pain score reductions from baseline by 0.5 hours post-dose.
    • There were no significant differences in adverse events or patient satisfaction levels between the two treatment arms.

    Conclusions:

    • Controlled-release codeine (CC) demonstrates equivalent analgesia onset and postoperative pain reduction compared to acetaminophen plus codeine (A/C).
    • Patient satisfaction levels were similar between CC and A/C treatments over the 48-hour postoperative period.
    • CC offers an advantage of less frequent dosing for managing pain after cholecystectomy.