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Updated: Jul 30, 2026
05:53
Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
AIDS-related cytomegalovirus retinitis
1AIDS Program, University of California, San Francisco, California 94110, USA.
Drugs of Today (Barcelona, Spain : 1998)
|March 11, 2004
Summary
New treatments for cytomegalovirus (CMV) retinitis in AIDS patients offer improved efficacy and convenience over older intravenous therapies. This review covers oral ganciclovir, intraocular devices, combination regimens, and cidofovir.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Virology
Background:
- Cytomegalovirus (CMV) retinitis historically affected one-third of AIDS patients, causing vision loss.
- Treatment options were limited to chronic daily intravenous ganciclovir or foscarnet.
Purpose of the Study:
- To review novel treatment modalities for acquired immunodeficiency syndrome (AIDS)-related CMV retinitis.
- To summarize key information for clinicians regarding available CMV disease treatments.
Main Methods:
- Review of randomized clinical trials on new CMV retinitis treatments.
- Analysis of novel treatment modalities including oral ganciclovir, ganciclovir intraocular device, combined intravenous ganciclovir/foscarnet, and cidofovir.
Main Results:
- New treatments demonstrate improved efficacy and/or reduced inconvenience compared to standard intravenous therapies.
- Oral ganciclovir, ganciclovir intraocular device, combination therapy, and cidofovir represent advancements in CMV retinitis management.
Conclusions:
- Several new treatment options are now available for CMV retinitis in AIDS patients.
- These advancements offer better patient outcomes and treatment experiences.
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