Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Male menopause.

T Mulligan1, M Godschalk

  • 1Section of Geriatrics Medicine and Division of General Medicine, Hunter Holmes McGuire VA Medical Center and Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia 23249, USA.

Drugs of Today (Barcelona, Spain : 1998)
|March 11, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antagonism of gamma-hydroxybutyrate-induced hypersynchronization in the ECoG of the rat by anti-petit mal drugs.

Neuroscience letters·2009
Same author

Prevalence of hypogonadism in males aged at least 45 years: the HIM study.

International journal of clinical practice·2006
Same author

Higher church attendance predicts lower fear of falling in older Mexican-Americans.

Aging & mental health·2005
Same author

Mechanisms of conjoint failure of the somatotropic and gonadal axes in ageing men.

Novartis Foundation symposium·2002
Same author

Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men.

The Journal of clinical endocrinology and metabolism·2002
Same author

Pulsatile iv infusion of recombinant human LH in leuprolide-suppressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male.

The Journal of clinical endocrinology and metabolism·2001
Same journal

Monoclonal antibodies for treatment of osteoporosis.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Tebentafusp: a novel drug for the treatment of metastatic uveal melanoma.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Sugemalimab, a novel PD-L1 inhibitor for treatment of advanced or metastatic non-small cell lung cancer.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Secukinumab, ixekizumab, bimekizumab and brodalumab for psoriasis and psoriatic arthritis.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Mitapivat for sickle cell disease and thalassemia.

Drugs of today (Barcelona, Spain : 1998)·2023
Same journal

Cenegermin for the treatment of dry eye disease.

Drugs of today (Barcelona, Spain : 1998)·2023
See all related articles

Older men experience hormonal changes similar to menopause, leading to reduced testosterone. Testosterone supplementation may offer benefits like increased muscle mass but requires monitoring for potential prostate cancer risks.

Area of Science:

  • Endocrinology
  • Aging Research
  • Men's Health

Background:

  • Menopause in women is linked to declining gonadal hormones.
  • Aging men also experience a decline in gonadal hormone secretion, termed 'male menopause'.
  • This decline is associated with reduced libido and muscle mass.

Purpose of the Study:

  • To explore the causes of decreased testosterone production in aging men.
  • To investigate the potential benefits and risks of testosterone supplementation in older men.

Main Methods:

  • Review of physiological changes associated with aging in men.
  • Analysis of factors contributing to reduced testosterone levels.
  • Examination of studies on testosterone supplementation outcomes.

Related Experiment Videos

Main Results:

  • Decreased testosterone may stem from reduced GnRH, impaired LH effects, or Leydig cell dysfunction.
  • Chronic illness exacerbates testosterone decline.
  • Testosterone supplementation may increase muscle protein synthesis and strength, and decrease cholesterol.

Conclusions:

  • Aging men face hormonal shifts impacting well-being.
  • Testosterone supplementation shows potential benefits for older men.
  • Vigilance for adverse effects, like prostate carcinoma growth, is crucial with testosterone therapy.