Related Experiment Video
Updated: Jul 24, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
Published on: May 3, 2017
Donepezil
1Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44120-1013, USA.
Abstract:
Donepezil is a highly selective, long-acting acetylcholinesterase inhibitor which has been approved in numerous countries for the treatment of Alzheimer's disease. Donepezil increases the levels of acetylcholine in the brain of patients with Alzheimer's disease and presumably corrects some dysfunction associated with loss of cells in the basal forebrain. Several large-scale multinational clinical studies have demonstrated drug-related improvements in cognitive performance on objective psychometric tests and in ratings by clinicians of patients' function. Further studies will be needed to determine the long-term impact of donepezil on Alzheimer's disease and related dementias.
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