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A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
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Preferred amino acids and thermostability.

Sávio T Farias1, Maria Christina M Bonato

  • 1Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270.901 Belo Horizonte, MG, Brasil. stfarias@yahoo.com.br

Genetics and Molecular Research : GMR
|March 11, 2004
PubMed
Summary

High-temperature prokaryotes utilize specific amino acid and codon patterns for protein stability. This study identifies an amino acid ratio (glutamate + lysine / glutamine + histidine) and codon usage as key markers for thermophilic adaptation.

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