Related Experiment Video

Updated: Aug 25, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Cleveland Clinic system doubles use of i.v. tPA

    Performance Improvement Advisor
    |March 12, 2004
    PubMed

    Insights

    Cleveland Clinic doubled tissue plasminogen activator use, significantly reducing brain bleeding complications. This achievement earned them the 2003 Ernest A. Codman Award for excellence in healthcare.

    Area of Science:

    • Neurology
    • Cardiology
    • Medical Quality Improvement

    Background:

    • Intravenous tissue plasminogen activator (tPA) is a critical treatment for acute ischemic stroke.
    • Hemorrhagic complications are a significant concern with tPA therapy.

    Purpose of the Study:

    • To evaluate the impact of increased tPA utilization on patient outcomes.
    • To assess the reduction in post-treatment brain hemorrhage frequency.

    Main Methods:

    • Analysis of treatment protocols and outcomes within the Cleveland Clinic Health System.
    • Comparative assessment of tPA usage rates and complication frequencies before and after protocol changes.

    Main Results:

    • Achieved a twofold increase in the administration of intravenous tPA.
    • Reduced the incidence of brain hemorrhagic complications by over 50%.

    Conclusions:

    • Optimized tPA administration protocols can enhance treatment efficacy.
    • Effective management strategies can significantly mitigate the risks associated with tPA therapy.

    More Related Videos

    Prehospital Thrombolysis: A Manual from Berlin05:52

    Prehospital Thrombolysis: A Manual from Berlin

    Published on: November 26, 2013

    Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide09:52

    Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

    Published on: January 15, 2017

    Related Concept Videos

    Imaging Studies for Cardiovascular System V: CT01:28

    Imaging Studies for Cardiovascular System V: CT

    Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
    Venous Thrombosis III: Interprofessional Care01:29

    Venous Thrombosis III: Interprofessional Care

    Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
    Cardiac Catheterization IV: Nursing Management01:26

    Cardiac Catheterization IV: Nursing Management

    Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...