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Sulfonylureas: a new class of cancer chemotherapeutic agents
F Mohamadi1, M M Spees, G B Grindey
1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Journal of Medicinal Chemistry
|August 7, 1992
Abstract:
This study summarizes the antitumor properties of a number of sulofenur thiophene analogs against subcutaneously implanted 6C3HED lymphosarcoma with structural modification of the aryl moiety of the sulfonamide portion of the diarylsulfonylureas. The spectrum of activity of N-(p-chlorophenyl)-N'- [(5-methoxy-2-thienyl)sulfonyl]urea in the HXGC3, VRC5, CX-1, and LX-1 cell lines is also presented.