Related Experiment Video
Updated: Aug 17, 2026

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors
G D Hartman1, W Halczenko, J D Prugh
1Merck Research Laboratories, Department of Medicinal Chemistry, West Point, Pennsylvania 19486.
Abstract:
Novel 5-[(alkylamino)methyl]thieno[2,3-b]furan-2-sulfonamides were prepared and evaluated in vitro for inhibition of human carbonic anhydrase II (CA II) and ex vivo for their ability to inhibit Ca II in the albino rabbit eye after topical administration. Compound 11a was found to lower intraocular pressure (IOP) in both the alpha-CT ocular hypertensive albino rabbit and the normal albino rabbit, but was ineffective at lowering IOP in a hypertensive, pigmented monkey model. Since 11a was highly bound to ocular pigment, a series of less basic analogs was prepared. Examples in this series were both less extensively bound to ocular pigment and more active at reducing IOP in pigmented rabbits after topical dosing. Key examples displayed moderate reactivity toward glutathione.
More Related Videos
10:42Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Related Concept Videos
2° Amines to N-Nitrosamines: Reaction with NaNO2
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Antihypertensive Drugs: Thiazide-Class Diuretics
Antiviral Nucleoside Inhibitors
Antifungal Agents
Anthelminthic Agents