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Practical de-O-acylation reactions promoted by molecular sieves
K P Ravindranathan Kartha1, Balaram Mukhopadhyay, Robert A Field
1Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160062, India. rkartha@niper.ac.in
Carbohydrate Research
|March 12, 2004
Abstract:
Methanol dried extensively over molecular sieves, or methanol in combination with powdered molecular sieves, serves as a good acceptor for acyl transfer reactions. Several O-acetylated and O-benzoylated sugar derivatives were efficiently de-O-acylated using this approach. In the case of per-O-acetylated N-acetylglucosamine, selective anomeric deprotection could be effected in high yield.