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Updated: Aug 25, 2026
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
Published on: October 22, 2019
A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [123I]CNS 1261
Rodrigo A Bressan1, Kjell Erlandsson, Rachel S Mulligan
1Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.
Abstract:
We have previously performed quantitative kinetic modeling of [(123)I]CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [(123)I]CNS 1261 in clinical populations.
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