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Updated: Aug 25, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Initial antiretroviral therapy in chronically-infected HIV-positive adults
Zelalem Temesgen1, Francesca Cainelli, David Warnke
1Mayo Clinic and Foundation, Division of Infectious Diseases, Rochester, MN 55905, USA. temesgen.zalalem@mayo.edu
Abstract:
Currently, there are 20 individual antiretroviral drugs and two co-formulation products that are approved by the FDA for the treatment of HIV-infected individuals. It is widely accepted that the selection of an appropriate first-line regimen is critical in assuring durable treatment response. This article reviews the factors that should be considered in the selection of an initial antiretroviral regimen and present the currently available evidence regarding the status of individual antiretroviral agents and treatment strategies relative to these factors.
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