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Linkage analysis of susceptibility to leprosy type using an IBD regression method
C Wallace1, J Fitness, B Hennig
1London School of Hygiene and Tropical Medicine, UK. c.wallace@qmul.ac.uk
Genes and Immunity
|March 12, 2004
Summary
Genetic factors influence leprosy type. A study in Malawi used identity by descent regression to find genetic determinants for leprosy, suggesting a link on chromosome 21q22.
Area of Science:
- Genetics
- Infectious Diseases
- Epidemiology
Background:
- Leprosy, caused by Mycobacterium leprae, presents a broad clinical spectrum.
- Host genetic factors are known to influence susceptibility to leprosy and its clinical forms.
Purpose of the Study:
- To identify genetic determinants for leprosy type.
- To apply identity by descent (IBD) regression analysis in families from Malawi.
Main Methods:
- Identity by descent (IBD) regression search was employed.
- Family-based genetic analysis was conducted in Karonga District, Northern Malawi.
Main Results:
- Suggestive evidence for linkage to leprosy type was found on chromosome 21q22.
- The linkage analysis yielded a P-value < 0.001.
Conclusions:
- Host genetics play a role in determining leprosy clinical type.
- The study highlights the utility of IBD regression for identifying genetic factors in leprosy.
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