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Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? A

M H Olsen1, K Wachtell, G de Simone

  • 1Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. mho@dadlnet.dk

Journal of Human Hypertension
|March 12, 2004
PubMed

Insights

Inappropriate left ventricular (LV) mass in hypertensive patients was not linked to arterial changes or measured growth factors. Unmeasured factors may contribute to excessive LV hypertrophy.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Hypertension Research

Background:

  • Left ventricular (LV) hypertrophy is a common complication of hypertension.
  • The relationship between inappropriately high LV mass and underlying pathophysiological mechanisms, including vascular changes and growth factor imbalances, requires further investigation.

Purpose of the Study:

  • To investigate the association between inappropriately high LV mass and structural vascular changes or imbalances in growth factors in hypertensive patients.

Main Methods:

  • Evaluated 53 hypertensive patients with LV hypertrophy.
  • Assessed 24-h ambulatory blood pressure, echocardiographic LV mass, stroke volume, stroke work, minimal forearm vascular resistance (MFVR), and carotid intima-media area (IMA).
  • Measured serum insulin, plasma epinephrine, norepinephrine, endothelin, angiotensin II, aldosterone, and brain natriuretic peptide (BNP).

Main Results:

  • High observed LV mass correlated with increased IMA, MFVR (in men), and 24-h systolic blood pressure, but with lower plasma angiotensin II.
  • Stroke work showed similar associations with IMA, MFVR, and plasma angiotensin II.
  • Inappropriate LV mass, defined by a ratio, was not significantly related to arterial or neurohormonal variables.

Conclusions:

  • In this cohort of older hypertensive patients, inappropriately high LV mass was not significantly associated with measured arterial changes or circulating growth factors.
  • Potential contributions of unmeasured factors, such as local myocardial alterations or genetic predisposition, to excessive LV hypertrophy warrant further study.

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