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Related Experiment Videos

Mood and Cognitive Changes During Systemic Corticosteroid Therapy.

E Sherwood Brown1, Patricia A. Chandler

  • 1Department of Psychiatry and the Department of Family Practice and Community Medicine, the University of Texas Southwestern Medical Center at Dallas, Dallas.

Primary Care Companion to the Journal of Clinical Psychiatry
|March 12, 2004
PubMed
Summary

Oral corticosteroid therapy can cause psychiatric and cognitive side effects like mood changes and memory deficits. These effects are common, dose-dependent, and often reversible with treatment.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Oral corticosteroids are widely prescribed, with ~10 million new prescriptions annually in the US.
  • Common side effects include weight gain, osteoporosis, and diabetes mellitus.
  • This review focuses on psychiatric and cognitive alterations associated with corticosteroid use.

Purpose of the Study:

  • To review existing literature on the psychiatric and cognitive side effects of corticosteroid therapy.
  • To identify the nature and prevalence of these adverse effects.
  • To explore potential treatment strategies for steroid-induced mood and cognitive disorders.

Main Methods:

  • Conducted a literature search of MEDLINE and psycINFO databases.
  • Utilized keywords such as 'corticosteroid,' 'prednisone,' 'mania,' 'depression,' 'psychosis,' 'mood,' 'memory,' and 'cognition.'

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  • Focused on clinically relevant articles detailing psychiatric and cognitive side effects.

    • Main Results:

    • Corticosteroid therapy is associated with psychiatric symptoms including hypomania, mania, depression, and psychosis.
    • Cognitive changes, particularly deficits in verbal or declarative memory, are also reported.
    • Psychiatric symptoms appear dose-dependent and typically emerge within the initial weeks of treatment.

    Conclusions:

    • Mood and cognitive alterations are frequent but generally mild and reversible side effects of corticosteroids.
    • Pharmacotherapeutic interventions like lithium and atypical antipsychotics may benefit patients requiring long-term corticosteroid treatment.
    • Further research is necessary to establish effective treatments for steroid-induced psychiatric conditions.