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Measurement of ethylenethiourea using thermospray liquid chromatography-mass spectrometry
P Kurttio1, T Vartiainen, K Savolainen
1National Public Health Institute, Department of Environmental Hygiene and Toxicology, Kuopio, Finland.
Journal of Analytical Toxicology
|March 1, 1992
Abstract:
Reliable measurement of ethylenethiourea (ETU) is important because ETU is a potent thyroid carcinogen. A method for the separation and identification of ethylenethiourea (ETU) by applying reversed-phase high-pressure liquid chromatography (HPLC) followed by thermospray (TSP) mass spectrometry (MS) detection is described. Single ion recording detection applying HPLC-MS of ETU appeared to be highly selective and equally sensitive as an HPLC method applying UV detection reported in our earlier study (1). The detection limit for ETU was 100 pg per injection.