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[Concentration of arsenic trioxide in animal tongue tissue by transartery catheterization]
1Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Second University, Shanghai 200021, China.
Objective:
To compare the differences of As(2)O(3) concentration in rabbit tongue tissue between arterial infusion and intravenous injection.
Methods:
4 clean rabbits were divided into the artery group and the vein group at random. The rabbits in both groups received arsenic trioxide of the same concentration and same volume. The tongue tissue from tip to the base of the rabbit were resected at 30,60,120,240 minutes after medication. The concentration in tissue of As(2)O(3) was determined with Gas Chromatography.
Results:
The concentration of As(2)O(3) in artery group is significantly higher than that in vein group (P<0.01). The average concentration was 7.9 micromol/L in artery group and 1.4 micromol/L in vein group.
Conclusion:
The concentration of As(2)O(3) infused by transartery catheterization was greatly enhanced in local tissue, it reached the concentration that can effectively inhibit the cell proliferation of oral tongue squamous cell carcinoma.
