Related Experiment Video
Updated: Aug 25, 2026
Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
[Experimental studies on the diel rhythm changes of blood cAMP in growthing rats after mandibular retraction]
1Department of Dentistry, Shanghai Seventh People's Hospital, Shanghai 200137, China.
Objective:
To document the effect of orthopedic therapy on the metabolism of rats.
Methods:
Exerting backwards force on rats mandible and measuring concentration of rats' blood cAMP in three groups with radio-immunity. Drawing the time-concentration curve and making cosine analysis.
Results:
In natural state, there was a diel rhythm change of concentration of cAMP in rats' blood(P<0.05); After being imposed orthopedic forces to inhibit mandibular growth, the normal diel rhythm of cAMP in blood still existed(P<0.05). The results of parameter-comparison among groups were more complicated.
Conclusion:
Further research is needed to clarify the mechanism whether local orthopedic forces influence the body metabolism.
