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[Experimental study of abnormal cell proliferation and differentiation in rat tongue carcinogenesis induced by 4NQO]
1Department of Oral and Maxillofacial Surgery, The Ninth People's Hospital, Shanghai Second Medical University. Shanghai 200011, China.
Objective:
To clarify the phenotypic characteristics of abnormal cell proliferation and differentiation in oral carcinogenesis.
Methods:
The expressions of gp230, a marker of epithelium cell differentiation, and proliferating cell nuclear antigen (PCNA) in rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide (4NQO) were detected by LSAB immunohistochemical staining.
Results:
With the progress of oral carcinogenesis abnormal proliferation and differentiation patterns were indicated by reduced expression of gp230 and increased expression of PCNA.
Conclusion:
Oral carcinogenesis is the result of mucosa epithelium cell aberrant proliferation and differentiation.
