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[Study on extraction process of zhanjin ruji]
Zhi-qian Du1, Tian-xin Du, Zhong-dong Wang
1Henan Provencial Institute of Luoyang Orthopedics, Luoyang 471002, Henan, China.
Summary
The optimal extraction of Radix Notoginseng involves using 60% alcohol with a 1:5 solvent ratio, repeated three times for one hour each. This method maximizes the extraction rate and total saponin content for Zhanjin Ruji.
Area of Science:
- Pharmacognosy and Phytochemistry
- Natural Product Chemistry
Context:
- Zhanjin Ruji is a traditional Chinese medicine formulation.
- Optimizing extraction processes is crucial for maximizing the yield and efficacy of active compounds from medicinal herbs.
- Radix Notoginseng is a key component in many traditional remedies, valued for its medicinal properties.
Purpose:
- To determine the most effective method for extracting active compounds from Radix Notoginseng for use in Zhanjin Ruji.
- To investigate the influence of various extraction parameters on the yield and concentration of target compounds.
Summary:
- An orthogonal experimental design was employed to optimize the alcohol extraction of Radix Notoginseng.
- Key factors investigated included alcohol concentration, extraction times, duration, and solvent volume.
- The optimal conditions identified were 60% alcohol, a 1:5 solvent ratio, and three extraction cycles of one hour each, yielding a 26.5% extraction rate and 17.28% mg/g total saponins.
Impact:
- Provides a scientifically validated extraction protocol for Radix Notoginseng in the preparation of Zhanjin Ruji.
- Establishes a basis for consistent and efficient production of herbal extracts.
- Contributes to the standardization of traditional Chinese medicine manufacturing processes.