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[Studies on stability of chlorogenic acid in extract of Flos lonicerae]
Gang Chen1, Shi-xiang Hou, Ping Hu
1Pharmaceutical Laboratory of Chinese Materia Medica, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
Objective:
To investigate the stability of chlorogenic acid in extract of flos lonicerae in different conditions.
Method:
The stability of chlorogenic acid in extract of flos lonicerae in phosptat buffe with different pH values, methanol, ethanol and different base solutions(Ca(OH)2 and NaOH) was investigated by the classical isothermal method.
Result:
The experiments showed the chlorogenic acid in extract of flos lonicerae was more stable in acidic water than in basic water. It was stable in these organic solutions and base solution[Ca(OH)2].
Conclusion:
In different conditions, the stability of chlorogenic acid in extract of flos lonicerae was different. It provided a reference to the extraction and analysis of chlorogenic acid and production of chlorogenic acid preparation.
