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Updated: Aug 25, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
[Comparative study on antibacterial effects of huangqin-tang and its metabolites produced by intestinal flora]
Mei-zhen Yan1, Feng Zuo, Hong-yue Song
1Institute of Chinese Material Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.
Objective:
To compare the antibacterial effects of Huangqin-Tang with its metabolites produced by intestinal flora.
Method:
The antibacterial tests in vitro and in vivo were performed by agar dilution method and lethal protection of animal respectively.
Result:
Huangqin-Tang and its metabolites had antibacterial action on bacteria in vitro, however the antibacterial activity of metabolites of Huangqin-Tang on Salmomella, Dysentery bacillus and Proteus in vitro was stronger than Huangqin-Tang. The metabolites of Huangqin-Tang had protective effect on the animals infected by Staphylococcus aureus and Escherichia coli respectively from death, but Huangqin-Tang had no lethal protection action.
Conclusion:
The antibacterial effects of metabolites of Huangqin-Tang in vitro and in vivo are stronger than that of Huangqin-Tang, which shows that intestinal flora play a very important role in antibacterial effects of Huangqin-Tang.
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