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Updated: Aug 9, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
[Effects of yixintong on regulating cellular calcium channels]
Si-cheng Li1, Hua Huang, Fei-ming Zheng
1First Hosptal of Chongqing Medicine University, Chongqing 400016, China. lsicheng@yahoo.com
Objective:
To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.
Method:
The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.
Result:
Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.
Conclusion:
Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.
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