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[Effect of daidzein on antiarrhythmia]
He-Yang Ye1, Feng Qiu, Jing Zeng
1Department of Pharmacology, Gan Nan Medical College, Ganzhou 341000, Jiangxi, China. heyangye@sohu.com
Objective:
To study the effect of Daidzein on Antiarrhythmia.
Method:
The conventional antiarrhythmia methods were used.
Result:
Daidzein was remarkedly effective in preventing ventricular fibrillation induced by chloroform in mice and arrhythmia induced by aconitine in rats. The arrhythmia induced by adrenalin in rabbits was antagonized by Daidzein and it could obviously inhibit the action potential amplitude of isolated sciatic nerves in toads. And it could also prevent ventricular fibrillation induced by calcium chloride in rats, and obviously reduce the death rate of rats. Its anti-arrhythmic effect was dose-dependent.
Conclusion:
Daidzein has obvious protective effect on drug-induced arrhythmia, which may be related to its inhibition of Na+ or Ca2+ influx and its blocking beta-adrenergic receptor.