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Central neurocytoma: a review
Meic H Schmidt1, Oren N Gottfried, Cornelia S von Koch
1Department of Neurological Surgery, University of Utah, Salt Lake City, UT 84132, USA. meic.schmidt@hsc.utah.edu
Journal of Neuro-Oncology
|March 16, 2004
Summary
Central neurocytomas are rare brain tumors. Maximal surgical resection offers the best prognosis, with radiation and re-operation as options for residual or recurrent tumors.
Area of Science:
- Neuro-oncology
- Central Nervous System Neoplasms
Background:
- Central neurocytomas are rare intraventricular neoplasms, accounting for 0.25-0.5% of brain tumors.
- Diagnosis and management remain challenging due to small clinical series and controversial approaches.
Purpose of the Study:
- To review findings from larger studies and case reports on central neurocytomas.
- To highlight current management strategies for these rare tumors.
Main Methods:
- Review of larger clinical series and significant case reports.
- Analysis of diagnostic and therapeutic modalities.
Main Results:
- Maximal safe surgical resection is the primary therapeutic modality for optimal long-term outcomes.
- Proliferation markers like MIB-1 may predict tumor relapse.
- Radiation therapy (external beam, conformal, radiosurgery) and re-operation are key for subtotal resection or recurrence.
Conclusions:
- Central neurocytomas typically have a favorable prognosis, but aggressive courses can occur.
- Multimodal treatment strategies including surgery, radiation, and potentially chemotherapy are crucial for managing central neurocytomas.
- Further research is needed to clarify optimal management protocols for these rare tumors.