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[Current guidelines for leprosy treatment].

B Flageul1

  • 1Service de dermatologie, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France. beatrice.flageul@sls.ap-hop-paris.fr

Bulletin De La Societe De Pathologie Exotique (1990)
|March 16, 2004
PubMed
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Multidrug therapy (MDT) has significantly reduced leprosy cases globally. However, new potent drugs are under investigation, and managing reactional states like reversal reactions is crucial to prevent nerve damage.

Area of Science:

  • Global health
  • Infectious diseases
  • Dermatology

Context:

  • Leprosy cases decreased significantly from 12 million in 1982 to 600,000 in 2000.
  • Despite this, approximately 700,000 new cases are detected annually.
  • Multidrug therapy (MDT) has proven highly effective with relapse rates below 1%.

Purpose:

  • To review current antibacillary and antireactional treatments for leprosy.
  • To assess the impact of MDT on leprosy prevalence and reactional states.
  • To highlight the importance of managing reversal reactions due to neurological damage risk.

Summary:

  • The global leprosy burden has decreased due to MDT, but new cases persist.
  • While MDT's efficacy is established, new drugs are being explored.

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  • The frequency of reversal reactions (Type 1) has increased, necessitating prompt diagnosis and treatment.

    • Impact:

    • MDT has drastically reduced leprosy prevalence worldwide.
    • Increased incidence of reversal reactions poses a significant risk of permanent neurological damage.
    • Further research on new antibacillary drugs and reaction management is essential for leprosy control.