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Updated: Aug 8, 2026

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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
[Gigantic keloïds after chicken-pox. A case report]
Bulletin De La Societe De Pathologie Exotique (1990)
|March 16, 2004
Summary
Gigantic keloids, tumors appearing after injury, are challenging to treat, especially when they grow after surgery. This case highlights difficulties in managing extensive keloid scarring in certain populations.
Area of Science:
- Dermatology
- Pathology
Background:
- Keloids are benign fibroproliferative tumors arising from skin injury or spontaneously.
- They disproportionately affect individuals with darker skin tones.
- Management of keloids remains a clinical challenge due to high recurrence rates and aesthetic concerns.
Observation:
- A case of a gigantic keloid developing after varicella (chickenpox) in a 29-year-old Black female is presented.
- The keloid appeared following a childhood viral infection at age 6.
- Significant tumor growth occurred even after surgical intervention, leading to severe unaesthetic outcomes.
Findings:
- The keloid's immense size and post-surgical exacerbation underscore the aggressive nature of keloid formation in this patient.
- Treatment resistance and recurrence post-surgery present significant clinical hurdles.
- The case highlights the need for advanced therapeutic strategies for extensive keloid scarring.
Implications:
- This case emphasizes the complex management of gigantic keloids, particularly in susceptible populations.
- It points to the limitations of current treatment modalities in preventing recurrence and achieving satisfactory aesthetic results.
- Further research into the pathophysiology and novel treatment approaches for keloids is warranted.
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