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Related Experiment Videos

Quadrant root planing versus same-day full-mouth root planing.

D A Apatzidou1, D F Kinane

  • 1Periodontal and Oral Immunology Research Group, Glasgow Dental School, Glasgow, UK.

Journal of Clinical Periodontology
|March 16, 2004
PubMed
Summary
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Both same-day full-mouth scaling and root planing (FM-SRP) and quadrant scaling and root planing (Q-SRP) reduced antibody titres against periodontal pathogens. While antibody avidity showed a trend to increase, significant differences were not observed between the two treatment approaches.

Area of Science:

  • Periodontology
  • Immunology
  • Microbiology

Background:

  • Chronic periodontitis involves a complex interplay between bacterial infection and the host immune response.
  • Humoral immunity, specifically antibody titres and avidity against periodontal pathogens, plays a crucial role in the host defense mechanism.
  • Understanding the impact of different periodontal treatment modalities on immune response dynamics is essential for optimizing patient outcomes.

Purpose of the Study:

  • To compare the systemic humoral immune response dynamics, including antibody titres and avidity, following same-day full-mouth scaling and root planing (FM-SRP) versus quadrant scaling and root planing (Q-SRP).
  • To evaluate short-term and long-term effects of these treatments on antibody responses to key periodontal pathogens.

Main Methods:

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  • Forty patients with chronic periodontitis were randomized into FM-SRP or Q-SRP groups.
  • Serum samples and clinical measurements were collected at baseline, post-treatment, and 6-month follow-up.
  • Antibody titres and avidity against five periodontal pathogens (P. gingivalis, A. actinomycetemcomitans, P. intermedia, T. denticola, B. forsythus) were measured using ELISA and thiocyanate dissociation.

    • Main Results:

    • Both FM-SRP and Q-SRP led to comparable reductions in antibody titres against most tested periodontal pathogens.
    • A trend for increased antibody avidity post-therapy was observed, but it did not reach statistical significance due to high inter-individual variability.
    • No evidence of increased antibody titres due to an inoculation effect was found following active treatment phases.

    Conclusions:

    • Both FM-SRP and Q-SRP effectively reduce antibody titres and show a trend towards increased antibody avidity in patients with chronic periodontitis.
    • No significant differences in humoral antibody dynamics were detected between the FM-SRP and Q-SRP treatment approaches.
    • Marked inter-subject variability influences the statistical significance of immune response changes following periodontal therapy.