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A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice

Marjorie Guitard1, Celine Leyvraz, Edith Hummler

  • 1Départment de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.

News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society
|March 16, 2004
PubMed

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Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...