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Related Experiment Videos

Glomerular changes in BK virus nephropathy.

Betul Celik1, Parmjeet S Randhawa

  • 1Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA.

Human Pathology
|March 16, 2004
PubMed
Summary
This summary is machine-generated.

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BK virus nephropathy (BKVN) can affect glomerular epithelium, with viral cytopathic effects and infection observed in some biopsies. While crescents may appear, rapidly progressive glomerulonephritis is not a feature of BKVN.

Area of Science:

  • Nephrology
  • Virology
  • Transplant Pathology

Background:

  • BK virus nephropathy (BKVN) is a significant complication following kidney transplantation.
  • Understanding glomerular involvement in BKVN is crucial for patient management.

Purpose of the Study:

  • To define the glomerular histopathologic changes associated with human BK virus nephropathy (BKVN).
  • To correlate these changes with viral load and clinical parameters.

Main Methods:

  • Histopathologic review of 124 renal allograft biopsies with viral nephropathy.
  • Diagnosis confirmed by immunohistochemistry or in situ hybridization.
  • Scoring of lesions using Banff 97 criteria and correlation with clinical data.

Main Results:

Related Experiment Videos

  • Viral cytopathic effect or infection of Bowman's capsular epithelium observed in 29% of biopsies.
  • Crescents present in 12% of biopsies; significant glomerulitis (Banff g1) was rare.
  • Common findings included ischemic glomerulopathy (62%) and chronic transplant glomerulopathy (62%).

Conclusions:

  • Glomerular epithelium infection occurs in a subset of BKVN patients, particularly with high viral loads.
  • Isolated crescents can be seen, but rapidly progressive glomerulonephritis is not characteristic.
  • Electron-dense deposits were occasionally found but their link to BK virus was uncertain.