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Updated: Aug 25, 2026
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
[Study on endotoxin levels of acute and chronic periapical periodontitis]
1Dept. of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Objective:
To compare the endotoxin levels between acute and chronic periapical periodontitis with different clinical symptoms.
Methods:
10 cases of acute periapical priodontitis(Group 1), 10 cases of chronic periapical periodontitis (group 2, the diameter of apical radiolucency area was less than 2 mm), 10 cases of chronic periapical periodontitis with sinus(group 3, the diameter of apical radiolucency area was greater than 2 mm), 10 cases of chronic periapical periodontitis without sinus (group 4, the diameter of apical radiolucency area was greater than 2 mm), were included in the study. Chromogenic substrate method of limulus amebocyte lysate(LAL) test was used to measure the endotoxin level.
Results:
Endotoxin concentrations in group 2 were significantly lower than those in group 1, group 3 and group 4(P < 0.01).
Conclusion:
Endotoxin plays a very important role in the initiation and development of periapical periodotitis and is closely associated with clinical symptoms and apical radiolucency degree.