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A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
Published on: December 9, 2017
Lower limit to the size of the primeval amino acid alphabet
1Institute for Biophysical Dynamics, Department of Computer Science, Ryerson Hall, The University of Chicago, Chicago, Illinois 60637, USA. ariel@uchicago.edu
Abstract:
Here I systematically examine the information complexity of all primary sequences of natural proteins deposited in the Swiss-Prot database. The sequence complexity is assessed by determining the frequency of occurrence of each amino acid type on sequence windows of fixed length, calculating the Shannon entropy of the window and then averaging over all windows covering the sequence. The minimum value in information content obtained from the present-day record imposes a lower limit in the number of letters that a primeval amino acid alphabet must have had.
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