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Updated: Aug 25, 2026

Functional Calcium Imaging in Developing Cortical Networks
Published on: October 22, 2011
From calcium interaction to calcium electrochemical detection by [(C5H5)Fe(C5H4COCH=CHC6H4NEt2)] and its two novel
Jérôme Maynadié1, Béatrice Delavaux-Nicot, Dominique Lavabre
1Laboratoire de Chimie de Coordination du CNRS, UPR 8241, 205 route de Narbonne, F-31077 Toulouse Cedex 04, France.
Abstract:
[(C(5)H(5))Fe(C(5)H(4)COCH=CHC(6)H(4)NEt(2))] (1) has been electrochemically evaluated toward different cations in solution. Calcium sensing by this compound and its two new derivatives [(C(5)H(5))Fe(C(5)H(4)CO(CH=CH)(2)C(6)H(4)NMe(2))] (2) and [(C(5)H(5))Fe(C(5)H(4)CH=CHCOCH=CHC(6)H(4)NEt(2))] (3) that exhibit a conjugated link between the ferrocene unit and the nitrogen atom has been thoroughly examined. Compounds 2 and 3 have been structurally characterized by single-crystal X-ray diffraction studies. The three related protonated species [1H][BF(4)] (4), [2H][BF(4)] (5), and [3H][BF(4)] (6) have been isolated in a good yield. NMR experiments clearly established that calcium interaction occurs in the vicinity of the carbonyl group, and mass spectrometry studies confirmed that this interaction, which involves several ligand-Ca(2+) adducts, is complex. A combination of electrochemical and NMR experiments highlighted an original salt influence on the electrochemical calcium sensing result.
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