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Recurrent gastroenteritis among infants in Western Australia: a seven-year hospital-based cohort study
Andy H Lee1, James Flexman, Kui Wang
1Department of Epidemiology & Biostatistics, School of Public Health, Curtin University of Technology, Perth, Western Australia, Australia. Andy.Lee@curtin.edu.au
Insights
Recurrent gastroenteritis in infants was more common in Aboriginal children and linked to dehydration. These findings highlight the need for targeted prevention strategies to reduce infant hospitalizations.
Area of Science:
- Pediatric Gastroenterology
- Public Health
- Epidemiology
Background:
- Gastroenteritis is a common cause of infant hospitalization.
- Understanding recurrence factors is crucial for effective public health interventions.
Purpose of the Study:
- To identify factors influencing recurrent gastroenteritis in infants in Western Australia (WA).
Main Methods:
- A 7-year retrospective cohort study of 514 infants born in 1995 admitted for gastroenteritis.
- Analysis of linked hospitalization records, including readmissions, diagnoses, demographics, and co-morbidities.
- Negative binomial regression model used to determine prognostic factors for recurrence.
Main Results:
- 23% of infants experienced recurrent gastroenteritis.
- Aboriginality (39% vs 15%) and dehydration at index admission were significantly associated with recurrence.
- Aboriginal infants accounted for 58% of recurrent cases.
Conclusions:
- Recurrent gastroenteritis hospitalizations are disproportionately higher among Aboriginal children in WA.
- Dehydration during the initial episode is a key factor in recurrence.
- Findings inform preventive strategies to mitigate the impact of gastroenteritis on infants.
Purpose:
To investigate factors that affect the frequency of recurrent gastroenteritis among infants in Western Australia (WA).
Methods:
A 7-year retrospective cohort study was undertaken on all infants born in 1995 who were admitted for gastroenteritis during their first year of life (n=514). Linked hospitalization records of the cohort were retrieved to derive the number of readmissions, microbiologic diagnoses, patient demographics, and co-morbidities at the index episode. A negative binomial regression model adjusting for inter-hospital variations was used to determine the prognostic factors influencing recurrent gastroenteritis.
Results:
Diarrhea with no specific etiology accounted for 54.7% of the cases presented at index admission and 55.8% of the total 676 admissions for the cohort. Of the 514 infants, 119 (23%) experienced repeated episodes of gastroenteritis. The lowest proportion of recurrences was 15.4% for patients initially admitted for bacterial or viral diarrhea. Over 85% of the recurrences from either bacterial and viral diarrhea or etiology unspecified were readmitted under the same category. Aboriginality and dehydration were significantly associated with the recurrence frequency, the adjusted incidence rate ratio being 2.86 (95% CI, 1.92-4.26) and 0.66 (95% CI, 0.49-0.88), respectively. Aboriginal infants contributed to 58% of those patients in the cohort who sustained repeated episodes of gastroenteritis. The proportion of patients with the recurrent disease was also significantly higher for Aboriginals (39%) than for non-Aboriginals (15%). The effect of dehydration was evident after accounting for within hospital correlations.
Conclusions:
Hospitalizations for recurrent gastroenteritis were more frequent among Aboriginal children than non-Aboriginal children in WA. Readmissions were also related to the presence of dehydration at the index episode. These findings have implications for preventive strategies to reduce the burden of gastroenteritis.
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