Related Experiment Video
Updated: Aug 25, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
The fellow eye of patients with rhegmatogenous retinal detachment
Christine R Gonzales1, Anurag Gupta, Steven D Schwartz
1Jules Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, 100 Stein Plaza, Los Angeles, CA 90095, USA. gonzales@jsei.ucla.edu
Objective:
To determine how often the fellow eyes of patients with rhegmatogenous retinal detachment (RRD) without proliferative vitreoretinopathy (PVR) harbor vision-threatening conditions at presentation and during follow-up.
Design:
Retrospective, observational case series.
Participants:
Two hundred forty-eight patients with RRD without PVR were studied.
Intervention:
The authors observed the fellow eye of patients with RRD for vision-threatening pathology.
Main Outcome Measure:
Detection of vision-threatening pathology in the fellow eye of patients with RRD without PVR.
Results:
Two hundred forty-eight patients were observed for an average of 5.2 years. One hundred fifty-seven vision-threatening events or diagnoses occurred in the fellow eye, including pre-existing and newly diagnosed conditions, 97 (62%) of which were rhegmatogenous in nature. Fifty-six patients (23%) had retinal detachments in their fellow eye, including those with a history of RRD repair (28 eyes), those presenting with bilateral RRD (4 eyes), and those developing new RRD during follow-up (24 eyes). In addition, 1 patient developed recurrent retinal detachment in the fellow eye during follow-up. Retinal tears were diagnosed and treated with laser retinopexy or cryotherapy in 30 (12%) fellow eyes (4 before the initial examination, 7 upon initial examination, and 19 on follow-up). Lattice degeneration was present in 27 (11%) fellow eyes.
Conclusions:
Patients who develop RRD are at considerable risk for developing vision-threatening events, particularly rhegmatogenous events, in the fellow eye.

