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Differences in mesentericin secretion systems from two Leuconostoc strains.

Willy Aucher¹, Valérie Simonet, Christophe Fremaux

¹Laboratoire de Microbiologie Fondamentale et Appliquée, EA 2224, IBMIG, 40 avenue du recteur Pineau, 86022 Poitiers, France.

FEMS Microbiology Letters

|March 17, 2004

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Leuconostoc mesenteroides strains Y105 and FR52 secrete bacteriocins mesentericin Y105 and B105 using a shared MesDE transport system. Despite sequence variations, this system effectively transports and matures both bacteriocins, highlighting its functional adaptability.

Area of Science:

Microbiology
Bacteriocin Research
Molecular Biology

Background:

Leuconostoc mesenteroides produces bacteriocins, including mesentericin Y105 and B105.
Bacteriocin production and secretion involve complex genetic and protein machinery.

Purpose of the Study:

To compare the mesentericin operons of L. mesenteroides Y105 and FR52.
To elucidate the role of the MesDE transport system in bacteriocin secretion and maturation.

Main Methods:

Operon sequencing and comparison.
Analysis of bacteriocin non-producing mutants.
Complementation experiments.

Main Results:

Differences in mesentericin operons were localized to the mesD and mesE genes, encoding the MesDE transport system.

Related Experiment Videos

The MesE protein is crucial for bacteriocin secretion in both strains.

The MesDE system efficiently transports and matures both mesentericin Y105 and B105, despite sequence variations between strains.

Conclusions:

The MesDE transport system is functionally conserved between L. mesenteroides Y105 and FR52.
This system plays a major role in bacteriocin secretion and maturation for both mesentericin Y105 and B105.