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Related Experiment Videos

Iontophoretic drug delivery.

Yogeshvar N Kalia1, Aarti Naik, James Garrison

  • 1School of Pharmacy, University of Geneva, Geneva, Switzerland. yogi.kalia@pharm.unige.ch

Advanced Drug Delivery Reviews
|March 17, 2004
PubMed
Summary

Iontophoresis enhances drug delivery across the skin's barrier, particularly for charged molecules. This technique offers controlled, individualized therapies, overcoming limitations of topical and transdermal drug administration.

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Area of Science:

  • Pharmacology
  • Biophysics
  • Drug Delivery

Background:

  • The stratum corneum presents a significant barrier to topical and transdermal drug delivery.
  • Physicochemical properties limit the range of molecules suitable for transdermal administration.
  • Interindividual variations in drug metabolism and efficacy are increasingly recognized.

Purpose of the Study:

  • To review the mechanisms and applications of iontophoresis for enhancing transdermal drug delivery.
  • To critically evaluate therapeutic agents and molecules investigated for iontophoretic delivery.
  • To discuss the influence of experimental parameters on iontophoretic efficiency.

Main Methods:

  • Review of existing literature on iontophoresis and transdermal drug delivery.

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  • Analysis of experimental parameters affecting iontophoretic delivery efficiency (drug concentration, current, pH).
  • Discussion of therapeutic classes, including peptides and proteins, suitable for iontophoresis.

    • Main Results:

    • Iontophoresis effectively enhances the penetration of hydrophilic and charged molecules across the skin.
    • Key parameters like drug concentration, applied current, and pH significantly impact delivery efficiency.
    • Various therapeutic classes have been explored for iontophoretic delivery, with peptides and proteins also discussed.

    Conclusions:

    • Iontophoresis offers a controlled and individualized approach to transdermal drug delivery, overcoming stratum corneum limitations.
    • Understanding interindividual variations will further optimize iontophoretic therapies.
    • Advancements include the development of pre-filled, pre-programmed iontophoretic devices.