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Updated: Aug 25, 2026

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
07:20

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity

Published on: December 21, 2012

Hepatocyte growth factor may be involved in cellular changes to the peritoneal mesothelium adjacent to pelvic

Tadayuki Ishimaru1, Khaleque Newaz Khan, Akira Fujishita

  • 1Department of Obstetrics and Gynecology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. tadayuki@net.nagasaki-u.ne.jp

Fertility and Sterility
|March 17, 2004
PubMed
Abstract

Insights

Hepatocyte growth factor (HGF) is linked to cellular changes in pelvic endometriosis, particularly in red lesions. Increased HGF correlates with macrophage infiltration, suggesting an inflammatory response in the peritoneum.

Area of Science:

  • Reproductive biology
  • Cellular and molecular pathology
  • Gynecological oncology

Background:

  • Pelvic endometriosis involves cellular changes in the peritoneum.
  • The role of specific growth factors in these changes is not fully understood.
  • Macrophage infiltration is observed in endometriosis, indicating an inflammatory component.

Purpose of the Study:

  • To investigate the involvement of hepatocyte growth factor (HGF) in the cellular alterations of pelvic mesothelium.
  • To explore the association between HGF, macrophage infiltration, and the stages of pelvic endometriosis.

Main Methods:

  • Controlled clinical study utilizing intact tissue biopsy specimens from women with pelvic endometriosis.
  • Immunohistochemical localization and quantitative analysis of hepatocyte growth factor (HGF) and CD68 (macrophage marker).
  • Correlation analysis between HGF expression and macrophage infiltration in relation to lesion appearance (red vs. black).

Main Results:

  • Pelvic mesothelium adjacent to red endometriotic lesions showed significantly higher HGF immunoreaction compared to areas near black lesions.
  • Greater macrophage infiltration was observed in mesothelial cells surrounding red lesions.
  • A significant positive correlation was found between HGF levels and macrophage accumulation in mesothelial cells near red lesions.

Conclusions:

  • The peritoneum adjacent to pelvic endometriosis may exhibit an inflammatory response.
  • Hepatocyte growth factor (HGF) appears to play a role in the cellular changes of the peritoneal mesothelium associated with pelvic endometriosis.

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