Heart rate dependent modification of the QTc cut-off values can improve accurate evaluation of QT prolongation
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Updated: Aug 25, 2026

Electrocardiogram Recordings in Anesthetized Mice using Lead II
Published on: June 20, 2020
Tsuneaki Sadanaga1, Fumiko Sadanaga, Hiroshi Yao
1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi-Ku, Fukuoka, Japan. kamefu@rb3.so-net.ne.jp
Abstract:
Significant amounts of over- and underestimation to detect QT prolongation were observed using Bazett's formula or Fridericia's formula for heart rate correction with any fixed QTc cut-off value. Heart rate dependent modification of the QTc cut-off values can improve accurate evaluation of QT prolongation.
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