Related Experiment Video
Updated: Aug 25, 2026

CD Spectroscopy to Study DNA-Protein Interactions
Published on: February 10, 2022
Multiple roles for ISWI in transcription, chromosome organization and DNA replication
Davide F V Corona1, John W Tamkun
1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 350 Sinsheimer Labs, Santa Cruz, CA 95064, USA.
Abstract:
ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.
Related Concept Videos
DNA Helicases
Replication in Eukaryotes
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes
DNA Topoisomerases
Types and Mechanism of action
Topoisomerases are divided into two main types. Type I...

