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[Diabetic patients after myocardial infarction]
1Diabeteszentrums am Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.
Insights
Diabetes mellitus significantly increases cardiovascular risk and is a precursor to heart attacks. Aggressively managing diabetes and related factors can substantially lower cardiovascular event risk in high-risk patients.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Context:
- Diabetes mellitus is a primary driver of global cardiovascular disease incidence.
- It represents maximal risk for target organ damage, particularly the cardiovascular system.
- Diabetes is often an unrecognized precursor to myocardial infarction and sudden cardiac death.
Purpose:
- To highlight the profound impact of diabetes mellitus on cardiovascular health.
- To underscore the elevated mortality and morbidity risks associated with diabetes post-myocardial infarction.
- To present evidence supporting intensive management of diabetes and cardiovascular risk factors.
Summary:
- Diabetes mellitus is not merely a risk factor but defines maximal cardiovascular risk.
- Approximately 75% of patients post-myocardial infarction (MI) have impaired glucose tolerance or diabetes.
- Data indicate that elevated risks in diabetics persist beyond the initial cardiovascular event.
Impact:
- The STENO-2 trial demonstrates that intensive management of diabetes and cardiovascular risk factors significantly reduces cardiovascular events.
- This approach offers a tangible strategy to mitigate severe outcomes in a high-risk diabetic population.
- Effective management can substantially lower the incidence of cardiovascular events and improve long-term prognosis for diabetic patients.
Abstract:
Diabetes mellitus is not just another risk factor for cardiovascular events; it per se defines maximal risk for target organ damage including the cardiovascular system. Diabetes is one of the main drivers in the race towards a higher incidence in cardiovascular disease worldwide. In addition, it is also one of the often unrecognized predecessors of myocardial infarction and sudden cardiac death. About three quarters of patients post-MI show impaired glucose tolerance or full blown diabetes. The MONICA/KORA data have shown that the higher risk for mortality and morbidity in diabetics is maintained past the first event. However, the STENO-2 trial has shown that consequently managing diabetes and concomitant cardiovascular risk factors can significantly reduce the risk for cardiovascular events in this high-risk group.
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