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Updated: Jul 11, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Substance misuse at presentation to an early psychosis program.

Sarah Van Mastrigt¹, Jean Addington, Donald Addington

¹Dept. of Psychiatry, University of Calgary, Calgary, Alberta, Canada.

Social Psychiatry and Psychiatric Epidemiology

|March 17, 2004

Summary

Substance misuse, particularly cannabis, is common in individuals experiencing their first episode of psychosis. This high prevalence, affecting 44% of patients, is linked to male gender, younger age, and earlier age of onset.

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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Area of Science:

Psychiatry
Clinical Psychology
Neuroscience

Background:

Substance misuse presents a significant challenge in schizophrenia treatment.
Early intervention in psychosis is crucial for long-term outcomes.

Purpose of the Study:

To determine the prevalence of substance misuse in individuals with first-episode psychosis.
To identify factors associated with substance misuse in this population at initial presentation.

Main Methods:

A cohort of 357 consecutive admissions to an early psychosis program was assessed.
Standardized measures included the Positive and Negative Syndrome Scale and depression/quality of life scales.

Main Results:

44% of patients met criteria for substance abuse/dependence, primarily alcohol or cannabis.
Prevalence significantly exceeded that of the general population.
Substance misuse correlated with male gender, younger age, and earlier age of onset.

Conclusions:

High rates of substance misuse, especially cannabis, are confirmed in first-episode psychosis.
Findings highlight the need for integrated treatment approaches for co-occurring substance use disorders.