[Effect of topical retinoid therapy on seborrhea using iontophoresis]

Increased sebum production is one of causes of Acne. This is under androgen control. Acne subjects have significantly greater sebum production than subjects without Acne and this relates to Acne's severity. Reduction in sebum production is associated with improvement in Acne and it can realize with anti-androgen therapy and isotretinoin therapy. But these therapies can not keep away from systematically influence. Topical retinoids do not affect sebum production and approximately 80% of tretinoin applied remains on the skin surface. Iontophoresis offer methods for enhancing the percutaneous absorption of drugs and increase of drug concentration in skin. The aim of the study was to establish possibility of improvement retinoin efficacy by iontophoresis. Our results show that application of tretinoin by iontophoresis do not affect on sebum production.