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Related Experiment Videos

[Trace elements and endemic goiter].

I V Tereshchenko, T P Goldyreva, V I Bronnikov

    Klinicheskaia Meditsina
    |March 17, 2004
    PubMed
    Summary
    This summary is machine-generated.

    Heavy metals accumulate in the thyroid gland (TG), indicating increased environmental pollution. This accumulation is linked to immune cell infiltration in TG tissue, suggesting health impacts from xenobiotics.

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    Area of Science:

    • Environmental Toxicology
    • Endocrinology
    • Pathology

    Context:

    • Thyroid gland (TG) function and morphology are susceptible to environmental xenobiotics.
    • Heavy metal salts (HMS) are prevalent environmental pollutants.
    • Anthropogenic pollution has increased over recent decades.

    Purpose:

    • To analyze the accumulation of xenobiotics, specifically heavy metal salts, in the thyroid gland.
    • To investigate the correlation between heavy metal accumulation and histological changes in thyroid tissue.
    • To assess the impact of environmental pollution on thyroid health over time.

    Summary:

    • Analysis of thyroid glands from 152 trauma victims across three decades (1960s, 1990s, 2000s) revealed significant accumulation of heavy metal salts (e.g., zinc, lead, copper, cadmium).

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  • Thyroid tissue demonstrated increasing levels of these xenobiotics over time, correlating with heightened environmental pollution in the Kama region.
  • Histological examination showed a marked increase in immunocompetent cell infiltration (lymphoid and plasma cells) in thyroid glands from individuals deceased after 2000, a change absent in earlier decades.
  • The findings suggest that heavy metal salts, acting as protoplasmic poisons, provoke immune responses within the thyroid gland.

    • Impact:

    • Demonstrates a clear link between environmental pollution and thyroid gland pathology.
    • Highlights the potential for xenobiotics to induce immune-mediated changes in endocrine organs.
    • Provides evidence for the aggravation of environmental pollution in the Urals region.
    • Suggests that improving environmental protection and implementing iodine prophylaxis are crucial for controlling goiter endemia.