Related Experiment Video
Updated: Aug 25, 2026
Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
Published on: December 27, 2024
[Neoadjuvant chemotherapy for locally advanced gastric cancer]
Katalin Kalmár1, László Cseke, Zsolt Káposztás
1PTE AOK Sebészeti Klinika, 7643 Pécs Ifjúság u. 13. kkalmar@aok.pte.hu
Unlabelled:
Only surgical resection offers cure in gastric cancer. Curative resection unfortunately is possible only in about every second patient diagnosed with gastric cancer. Neoadjuvant chemotherapy may help to reach R0 resection in patients with locally advanced gastric cancer.
Aim:
To evaluate the ability of ECF neoadjuvant chemotherapy in locally advanced gastric cancer.
Patients And Methods:
Between December 1998 and April 2003 twenty-four patients with locally advanced gastric cancer were given neoadjuvant chemotherapy according to the ECF scheme. Before treatment, staging examinations were carried out: endoscopy, barium swallow, chest X-ray, computer-tomography and laparotomy or diagnostic laparoscopy. We treated patients with four three-weeks-long courses of chemotherapy with bolus injection of epirubicin and cisplatin on day 1, and continuous infusion of 5-fluorouracil on day 1 to 21. Twelve weeks long treatment was followed by 4 weeks free of treatment, than staging was repeated to determine response.
Results:
45.83% response rate was achieved. One complete response was observed. Ten patients showed partial response, 3 stable diseases and 10 progressive disease were detected. Twenty-one patients were operated on. Sixteen resections were carried out, ten with curative intent. Overall survival and disease free survival in the whole group were 12.19 and 8.66 months, while in patients with R0 resection 20.66 and 18.33 months.
Conclusion:
Neoadjuvant chemotherapy provides a hope for cure for patient with locally advanced gastric cancer.
