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Related Experiment Videos

[Candida infections in newborns].

Y Aujard1, C Farnoux, S Lefevre

  • 1Service de néonatologie, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France. yannick.aujard@rdb.ap-hop-paris.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|March 17, 2004
PubMed
Summary

Neonatal Candida infections, often nosocomial in premature infants, are increasingly treated with fluconazole due to its safety and efficacy. Prophylactic fluconazole use in colonized newborns is a promising new strategy.

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Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Mycology

Context:

  • Neonatal Candida infections present as early-onset (maternofetal) or late-onset (nosocomial) diseases.
  • While early-onset Candida sepsis is rare (<1%), nosocomial infections affect 7% of premature infants (<1500g), often linked to central venous catheters or skin infections.
  • Candida albicans dominates in maternogenesisital infections, whereas Candida parapsilosis is more prevalent (60%) in nosocomial infections.

Purpose:

  • To review the classification, diagnosis, and treatment of Candida infections in newborns.
  • To highlight the shift in species prevalence between maternogenesisital and nosocomial Candida infections.
  • To discuss the role of fluconazole and Amphotericin B in managing neonatal candidiasis.

Summary:

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  • Candida infections in neonates are categorized into early-onset and late-onset types, with nosocomial infections being more common in premature infants.
  • Diagnosis can be aided by skin lesions, and while Candida albicans is common in early-onset cases, Candida parapsilosis predominates in nosocomial infections.
  • Both C. albicans and C. parapsilosis are sensitive to fluconazole, which is preferred over Amphotericin B due to lower toxicity and ease of administration. Prophylactic fluconazole is being explored for colonized premature infants.

    • Impact:

    • Provides an overview of neonatal candidiasis, aiding clinicians in diagnosis and treatment strategies.
    • Emphasizes the importance of differentiating Candida species for appropriate antifungal selection.
    • Supports the consideration of fluconazole for both treatment and potential prophylaxis in high-risk neonatal populations.