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Lipoblastomatosis--a case report
Jayati Mitra1, Uttara Chatterjee, Subir Kumar Chatterjee
1Department of Pathology, R G Kar Medical College and UCM, Kolkata.
Insights
Lipoblastomatosis is a rare benign childhood fatty tumor. This case highlights a recurrent lipoblastomatosis in an infant, with histological analysis revealing immature adipose tissue and lipoblasts.
Area of Science:
- Pediatric Oncology
- Surgical Pathology
- Soft Tissue Tumors
Background:
- Lipoblastoma and lipoblastomatosis are rare, benign, adipocytic soft tissue tumors exclusively occurring in children.
- These tumors are typically located in the trunk, extremities, or head and neck regions.
Observation:
- A 5-month-old male infant presented with a recurrent lump in the left scapular region, previously operated on two months prior.
- Histological examination of both excisions revealed an adipocytic tumor consistent with lipoblastomatosis.
Findings:
- Microscopic analysis showed lobules of immature adipose tissue separated by fibrous septa, with numerous lipoblasts at various differentiation stages and myxoid material.
- The second excision specimen demonstrated a higher proportion of mature adipose tissue compared to the initial tumor.
Implications:
- Recurrence of lipoblastomatosis is possible, necessitating thorough histological evaluation of subsequent resections.
- Understanding the histological spectrum, including varying degrees of adipocyte maturation, is crucial for accurate diagnosis and management of pediatric lipoblastomatosis.
Abstract:
Lipoblastoma and lipoblastomatosis are benign fatty tumors of soft tissues that are unique to childhood. A male infant aged 5 months presented with a history of recurrent lump in the left scapular region. He had been operated upon for the same lump 2 months earlier. A review of the histology of the two consecutive lumps showed an adipocytic tumor. Microscopically the tumor was composed of lobules of immature adipose tissue separated by thick fibrous septae. Plentiful lipoblasts were noted in various stages of differentiation and myxoid material was also present. A diagnosis of lipoblastomatosis was made. The second excision had a higher proportion of mature adipose tissue.
