Related Experiment Video

Updated: Aug 25, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
08:27

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat

Published on: October 29, 2014

Outbreak of neonatal meningitis caused by Salmonella enterica serotype Worthington

Dnyaneshwari Ghadage1, Abhijit Bal

  • 1Department of Microbiology, B.J. Medical College, Pune.

Indian Journal of Pathology & Microbiology
|March 17, 2004
PubMed

Insights

An outbreak of Salmonella meningitis caused by serotype Worthington affected five infants in a nursery. The bacteria showed resistance to common antibiotics but remained sensitive to ciprofloxacin, highlighting an emerging threat in neonatal units.

Area of Science:

  • Neonatal infectious diseases
  • Bacteriology
  • Clinical microbiology

Background:

  • Salmonella meningitis is a severe infection in infants.
  • Neonatal units are vulnerable to outbreaks of multidrug-resistant organisms.
  • Salmonella serotype Worthington has been infrequently reported in neonatal settings.

Purpose of the Study:

  • To report an outbreak of Salmonella meningitis in a nursery unit.
  • To characterize the antibiotic resistance profile of the causative agent.
  • To highlight the emerging threat of Salmonella serotype Worthington in neonates.

Main Methods:

  • Clinical case reporting of five affected infants.
  • Bacterial isolation and identification from blood and cerebrospinal fluid (CSF) samples.
  • Antimicrobial susceptibility testing of Salmonella isolates.

Main Results:

  • Salmonella serotype Worthington was identified as the causative agent in five neonates.
  • Isolates exhibited resistance to ampicillin, cefotaxime, ceftriaxone, and amikacin.
  • All isolates were sensitive to ciprofloxacin.

Conclusions:

  • Salmonella serotype Worthington is an emerging pathogen in neonatal intensive care units.
  • Antibiotic resistance necessitates careful selection of empirical therapy.
  • Ciprofloxacin may be a viable treatment option for infections caused by this resistant strain.

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...