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Updated: Aug 25, 2026

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
LC-SSI-MS techniques as efficient tools for characterization of nonvolatile phenolic compounds of a special Hungarian
Zsuzsanna Kovács1, Zoltán Dinya, Sándor Antus
1Eszterházy Károly College, Department of Chemistry, H-3300, Eger, Leányka street 4., Hungary.
Abstract:
The utility of high-performance liquid chromatography-mass spectrometry using electrospray (ESI) and sonic spray (SSI) ionization for the characterization of nonvolatile phenolic compounds is tested using the special Hungarian wine Tokaj aszu of 1983 vintage. Besides caffeic-, ferrulic-, chlorogenic-, and 3,4-dimethoxycinnamic acids; 3,4-dimethoxycinnamoyl-, ferruloyl-, and galloyl-glucose; gentisic acid-beta-D-glucoside; theogallin; and resveratrol-3-O-beta-D-glucoside, 26 flavonoids can be identified. It is shown that because of its higher sensitivity, SSI is a more powerful tool for characterization and monitoring of nonvolatile phenolic compounds than ESI.

