Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammation and atherosclerosis.

Mehdi H Shishehbor1, Deepak L Bhatt

  • 1Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F25, Cleveland, OH 44195, USA.

Current Atherosclerosis Reports
|March 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hospital variation in intravenous inotrope use for patients hospitalized with heart failure: insights from Get With The Guidelines.

Circulation. Heart failure·2014
Same author

Unintentional overestimation of an expected antihypertensive effect in drug and device trials: mechanisms and solutions.

International journal of cardiology·2014
Same author

Saxagliptin, alogliptin, and cardiovascular outcomes.

The New England journal of medicine·2014
Same author

Quality of care for patients with acute coronary syndromes as a function of hospital revascularization capability: Insights from get with the guidelines-CAD.

Clinical cardiology·2014
Same author

Peripheral artery disease is a coronary heart disease risk equivalent among both men and women: results from a nationwide study.

European journal of preventive cardiology·2014
Same author

Obstructive sleep apnea and diurnal nondipping hemodynamic indices in patients at increased cardiovascular risk.

Journal of hypertension·2013

Inflammation is key in atherosclerosis development and predicts heart attack risk. Targeting inflammation may offer new treatments for cardiovascular disease.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathophysiology

Background:

  • Inflammation is integral to all phases of atherosclerosis, from initial foam cell development to plaque rupture and thrombosis.
  • Recent research highlights the diagnostic and prognostic value of understanding inflammation's role in atherosclerosis.
  • Chronic low-grade inflammation is a significant predictor of cardiovascular events.

Purpose of the Study:

  • To explore the critical role of inflammation in the pathogenesis of atherosclerosis.
  • To investigate the predictive value of inflammatory markers for cardiovascular events.
  • To identify potential therapeutic targets for atherosclerosis based on inflammatory pathways.

Main Methods:

  • Review of current basic and clinical research linking inflammation and atherosclerosis.

Related Experiment Videos

  • Analysis of data on high-sensitivity C-reactive protein as a predictor of acute coronary syndrome.
  • Evaluation of the impact of "inflammatory burden" on risk reduction with therapy.

    • Main Results:

    • High-sensitivity C-reactive protein levels predict acute coronary syndrome risk independently of traditional factors.
    • Individuals with a higher inflammatory burden experience greater risk reduction from aggressive therapies.
    • Inflammation is a central mechanism throughout the entire atherosclerotic process.

    Conclusions:

    • Inflammation is a critical driver of atherosclerosis, offering diagnostic and prognostic insights.
    • Inflammatory markers like C-reactive protein are valuable in assessing cardiovascular risk.
    • Inhibiting inflammation presents a promising therapeutic strategy for slowing atherosclerosis progression.